反应详情

4-Chloro-3-ethoxycarbonyl-7-methoxyquinoline (43 g, 162 mmol) was dissolved in acetic acid (250 ml), with 10% palladium on charcoal (1.5 g) and hydrogenated at atmospheric pressure during 8 hours. The catalyst was removed by filtration over a pad of celite and the solvent evaporated. The residue was diluted with water and the pH adjusted to 7-8 with a saturated solution of sodium hydrogen carbonate. The solid was collected by filtration, washed with water and dried under vacuum over phosphorus pentoxide to give 3-ethoxycarbonyl-7-methoxyquinoline (33g, 88%) as a beige powder.

1. customThe catalyst was removed by filtration over a pad of celite
2. customthe solvent evaporated
3. additionThe residue was diluted with water
4. filtrationThe solid was collected by filtration
5. washwashed with water
6. dry with materialdried under vacuum over phosphorus pentoxide