HCID 22030632, compound → HCID 22030777, compound

HRID 454211Notes

Reaction equation

HRID 454211 reaction equation
[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([NH:12][C:13]3[CH:14]=[C:15]4[C:19](=[CH:20][CH:21]=3)[NH:18][C:17]([CH3:22])=[CH:16]4)=[N:7][CH:8]=[N:9]2)=[CH:4][C:3]=1[O:23][CH3:24].O[CH2:26][CH2:27][CH2:28][N:29]1[CH:33]=[CH:32][N:31]=[C:30]1[CH3:34]>>[CH3:24][O:23][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:2]=1[O:1][CH2:26][CH2:27][CH2:28][N:29]1[CH:33]=[CH:32][N:31]=[C:30]1[CH3:34])[N:9]=[CH:8][N:7]=[C:6]2[NH:12][C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[NH:18][C:17]([CH3:22])=[CH:16]2

Participants

3

Reactant 2

HCID 22030632HCID 22030632, compoundHCID 135763120HCID 135763120, compound

Product 1

HCID 22030777HCID 22030777, compoundYield 37.4%

Procedure

Using an analogous procedure to that described in Example 224, 7-hydroxy-6-methoxy-4-(2-methylindol-5-ylamino)quinazoline (102 mg, 0.32 mmol), (prepared as described for the starting material in Example 205), was reacted with 1-(3-hydroxypropyl)-2-methylimidazole (67 mg, 0.48 mmol), (EP 0060696 A1), to give 6-methoxy-7-(3-(2-methylimidazol-1-yl)propoxy)-4-(2-methylindol-5-ylamino)quinazoline (53 mg, 37%).

Workup

  1. custom(prepared

Sources & evidence

ORD record
ord-826643a683ff474fa96cfbbf75226f24
Source dataset
uspto-grants-2013_07
Patent number
US08492560B2

Reaction notes

Loading…