HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 4-(6-Fluoroindol-5-yloxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Chloro-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazoline | HCID 11141792 | — |
| Reactant | 6-Fluoro-1H-indol-5-ol | HCID 22030929 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-(6-Fluoroindol-5-yloxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline | HCID 10296728 | 53.3% |
Reaction Steps
Using an analogous procedure to that described in Example 243, 4-chloro-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline (213 mg, 0.662 mmol), (prepared as described for the starting material in Example 9), was reacted with 6-fluoro-5-hydroxyindole (120 mg, 0.794 mmol), (prepared as described for the starting material in Example 242), in DMF (3 ml) containing potassium carbonate (137 mg, 0.993 mmol) to give 4-(6-fluoroindol-5-yloxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline (154 mg, 53%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08492560B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-484b102c75ff40fca44434df9cf18426 |
| Source note | uspto-grants-2013_07 |