HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 454244Generated: October 31, 2026
Potassium Carbonate → HCID 10114834, compound
https://huagongshe.com/reaction/454244
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Chloro-6-methoxy-7-(3-(piperidin-1-YL)propoxy)quinazoline | HCID 11002191 | — |
| Reactant | 4-fluoro-1H-indol-5-ol | HCID 22030553 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 10114834 | HCID 10114834 | 67.3% |
Reaction Steps
Using an analogous procedure to that described in Example 244, 4-chloro-6-methoxy-7-(3-piperidinopropoxy)quinazoline (407 mg, 1.21 mmol), (prepared as described for the starting material in Example 67), 4-fluoro-5-hydroxyindole (220 mg, 1.45 mmol) (prepared as described for the starting material in Example 242), and potassium carbonate (251 mg, 1.82 mmol) in DMF (6 ml) were heated at 95° C. for 90 minutes and purified to give 4-(4-fluoroindol-5-yloxy)-6-methoxy-7-(3-piperidinopropoxy)quinazoline (367 mg, 67%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08492560B2 |
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| Source dataset | uspto-grants-2013_07 |
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| ORD ID | ord-29821e66ea1247cc8be4713bc1700268 |
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| Source note | uspto-grants-2013_07 |
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