反应详情

A solution of 5-benzyloxy-1-methylindole (3.5 g, 15.7 mmol), in ethanol (100 ml) was hydrogenated at ambient temperature and 1 atmosphere pressure hydrogen for 4 hours using 10% palladium on carbon (0.5 g) as catalyst. The catalyst was filtered off and the filtrate evaporated in vacuo. The residue was purified by silica column chromatography eluting with ethyl acetate/dichloromethane (10/90) to give 5-hydroxy-1-methylindole (2.1 g, 97%).

1. customwas hydrogenated at ambient temperature
2. filtrationThe catalyst was filtered off
3. customthe filtrate evaporated in vacuo
4. customThe residue was purified by silica column chromatography
5. washeluting with ethyl acetate/dichloromethane (10/90)