Morpholine → (2R)-7-(2-hydroxy-3-morpholinopropoxy)-4-(indol-5-yloxy)-6-methoxyquinazoline

Participants

Role	Name	HCID	Charge
Reactant	Morpholine	HCID 8083	—
Reactant	HCID 53976813	HCID 53976813	—
Product	(2R)-7-(2-hydroxy-3-morpholinopropoxy)-4-(indol-5-yloxy)-6-methoxyquinazoline	HCID 53646567	90.4%

Reaction Steps

Using an analogous procedure to that described in Example 292, (2R)-4-(indol-5-yloxy)-6-methoxy-7-(oxiran-2-ylmethoxy)quinazoline (300 mg, 0.83 mmol), (prepared as described for the starting material in Example 292), was reacted with morpholine (211 mg, 2.49 mmol) to give (2R)-7-(2-hydroxy-3-morpholinopropoxy)-4-(indol-5-yloxy)-6-methoxyquinazoline (338 mg, 85%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08492560B2
Source dataset	uspto-grants-2013_07
ORD ID	ord-e4a78205ae05445d8df697c84ee0dca4
Source note	uspto-grants-2013_07