Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Ethylamine hydrochloride | HCID 11198 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-bromo-N-(3,5-dibromopyrazin-2-yl)acetamide | HCID 58298307 | — |
| Reactant | 6-Bromo-4-ethyl-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one | HCID 86644654 | — |
| Product | HCID 178462798 | HCID 178462798 | 36% |
Reaction Steps
6-Bromo-4-ethyl-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one. To a solution of 2-bromo-N-(3,5-dibromopyrazin-2-yl)acetamide (See Example 4.A) (1 equiv) and diisopropylethylamine (3 equiv) in acetonitrile was added ethanamine hydrochloride (1.05 equiv). The solution was allowed to heat to 70° C. for 30 min. The solution was condensed under reduced pressure and purified using column chromatography (0-75% ethyl acetate in hexanes) to afford the title compound in 36% yield. MS (ESI) m/z 257.5 [M]+, 259.4 [M+2]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08492381B2 |
|---|
| Source dataset | uspto-grants-2013_07 |
|---|
| ORD ID | ord-2db519be980243cdb7b5fd0ed494755f |
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| Source note | uspto-grants-2013_07 |
|---|
