HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methyl-1-pentyne → 2,2,2-Trifluoro-n-(3-hydroxy-3-(3-(4-methylpent-1-ynyl)phenyl)propyl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methyl-1-pentyne | HCID 138948 | — |
| Reactant | N-(3-(3-bromophenyl)-3-hydroxypropyl)-2,2,2-trifluoroacetamide | HCID 57608426 | — |
| Product | 2,2,2-Trifluoro-n-(3-hydroxy-3-(3-(4-methylpent-1-ynyl)phenyl)propyl)acetamide | HCID 87081518 | — |
Reaction Steps
Sonogashira reaction of 25 with 4-methyl-pent-1-yne yielded 2,2,2-trifluoro-N-(3-hydroxy-3-(3-(4-methylpent-1-ynyl)phenyl)propyl)acetamide as dark brown oil. Yield (0.94 g, 94%): 1H NMR (400 MHz, CDCl3) δ 7.38 (s, 1H), 7.25-7.35 (m, 3H), 4.86 (m, 1H), 3.67-3.72 (m, 1H), 3.38-3.44 (m, 1H), 2.30 (d, J=6.4 Hz, 2H), 2.28 (bs, 1H), 1.87-1.99 (m, 3H), 1.05 (d, J=6.8 Hz, 6H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08492589B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-de1cdd28d314433c99deaa8d14484d1c |
| Source note | uspto-grants-2013_07 |