HRID454408

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID87074

Cyclopentanol, 1-ethynyl-

C7H10O

HCID57608426

N-[3-(3-Bromophenyl)-3-hydroxypropyl]-2,2,2-trifluoroacetamide

C11H11BrF3NO2

PRODUCTS

生成物

结构：O=C(NCCC(O)c1cccc(C#CC2(O)CCCC2)c1)C(F)(F)F

HCID86628474

未命名化合物

PROCEDURE

实验过程

Sonogashira reaction of bromide 25 with 1-ethynylcyclopentanol yielded 2,2,2-trifluoro-N-(3-hydroxy-3-(3-((1-hydroxycyclopentyl)ethynyl)phenyl)propyl)-acetamide as brown oil. Yield (0.55 g, 55%): 1H NMR (400 MHz, CDCl3) δ 7.41 (s, 1H), 7.28-7.35 (m, 3H), 4.85-4.87 (m, 1H), 3.66-3.70 (m, 1H), 3.38-3.44 (m, 1H), 2.41 (bs, 1H), 1.76-2.08 (m, 10H).