HCID 67103776, compound → (2'-(Benzyloxy)-3'-tert-butylbiphenyl-3-yl)(pyridin-2-yl)methanone

Participants

Reaction Steps

A solution of crude 10 (6.1 mmol) in dichloromethane (80 mL) was treated with manganese dioxide (85%, 8 g, 15 equiv.) and this suspension was stirred at reflux for 3 hr. The solids were filtered out and washed with ethyl acetate. The solvent was removed in a rotary evaporator and the residue was purified by chromatography on silica (80 g) with 5% ethyl acetate in heptane (1 L) and 7.5% ethyl acetate in heptane (3 L) to afford pure 11 (1.64 g, 60% over 2 steps).

Provenance & Evidence