反应详情

A 2 mol/L aqueous solution of sodium hydroxide (1.3 mL) was added to a solution mixture of the obtained benzyl 2-(benzyloxy)-3-(pyridin-3-yl)benzoate (0.35 g) in dioxane (3.5 mL) and methanol (3.5 mL), followed by stirring at room temperature for 1 hour. A 2 mol/L aqueous solution of sodium hydroxide (1.3 mL) was added to the reaction mixture, followed by stirring at room temperature for 1 hour. The solvent was evaporated under reduced pressure, and water was added to the residue. After adjusting the pH to 4.5 with 6 mol/L hydrochloric acid, ethyl acetate was added thereto. The organic layer was separated, washed with a saturated aqueous solution of sodium chloride, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. Diisopropyl ether was added to the obtained residue, and the solid substance was collected by filtration to obtain 0.18 g of 2-(benzyloxy)-3-(pyridin-3-yl)benzoic acid as a white solid.

1. stirringby stirring at room temperature for 1 hour
2. customThe solvent was evaporated under reduced pressure, and water
3. additionwas added to the residue
4. additionwas added
5. customThe organic layer was separated
6. washwashed with a saturated aqueous solution of sodium chloride
7. dry with materialdried over anhydrous magnesium sulfate
8. customthe solvent was evaporated under reduced pressure
9. additionDiisopropyl ether was added to the obtained residue
10. filtrationthe solid substance was collected by filtration