Sodium Hydroxide → 2-(Benzyloxy)-5-(oxazol-5-yl)benzoic acid

Participants

Reaction Steps

A 2 mol/L aqueous solution of sodium hydroxide (4.5 mL) was added to a dioxane (5 mL) solution of the obtained methyl 2-(benzyloxy)-5-(oxazol-5-yl)benzoate (0.55 g), followed by stirring at room temperature for 2 hours and 40 minutes. The solvent was evaporated under reduced pressure, and water was added to the residue. After adjusting the pH to 4.0 with 6 mol/L hydrochloric acid, the solid substance was collected by filtration to obtain 0.46 g of 2-(benzyloxy)-5-(oxazol-5-yl)benzoic acid as a light yellow solid.

Provenance & Evidence