Trimethyl orthoformate → HCID 66990222, compound

Participants

Reaction Steps

A trimethyl orthoformate (2 mL) suspension of the obtained benzyl 2-(benzyloxy)-5-(hydrazinocarbonyl)benzoate (0.20 g) was heated to reflux for 1 hour and 30 minutes. The reaction mixture was cooled to room temperature, and then the solvent was evaporated under reduced pressure. Ethyl acetate and diisopropyl ether were added to the obtained residue, and 0.16 g of the solid substance was collected by filtration. The obtained solid substance (0.11 g) was stirred at 200° C. for 15 minutes. The reaction mixture was cooled to room temperature and then purified by silica gel column chromatography [Kanto Chemical Co., Inc., silica gel 60 (spherical), eluent: 90-50% hexane/ethyl acetate] to obtain 0.079 g of benzyl 2-(benzyloxy)-5-(1,3,4-oxadiazol-2-yl)benzoate as a white solid.

Provenance & Evidence