Trifluoroacetic acid → HCID 66990568, compound

Participants

Reaction Steps

Under ice-cooling, trifluoroacetic acid (1.3 mL) was added to a methylene chloride (6.5 mL) solution of methyl 2-(2-(benzyloxy)-5-(1-(tert-butoxycarbonyl)piperidin-4-yl)benzamido)-4-bromobenzoate (0.65 g), followed by stirring at room temperature for 30 minutes. The reaction mixture was added to a saturated aqueous solution of sodium bicarbonate under ice-cooling. The organic layer was separated, washed with a saturated aqueous solution of sodium bicarbonate, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to obtain 0.54 g of methyl 2-(2-(benzyloxy)-5-(piperidin-4-yl)benzamido)-4-bromobenzoate as a white solid.

Provenance & Evidence