Trifluoroacetic acid → HCID 66990423, compound

Participants

Reaction Steps

Trifluoroacetic acid (4.5 mL) was added to a methylene chloride (2.0 mL) solution of methyl 4-(2-((tert-butoxycarbonyl)(ethyl)amino)phenyl)-2-nitrobenzoate (0.39 g) at room temperature, followed by stirring at the same temperature for 1 hour. The solvent was evaporated under reduced pressure, and ethyl acetate and a saturated aqueous solution of sodium bicarbonate were added to the residue. The organic layer was separated, washed with a saturated aqueous solution of sodium chloride, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography [eluent: 91-85% hexane/ethyl acetate] to obtain 0.27 g of methyl 4-(2-(ethylamino)phenyl)-2-nitrobenzoate as an orange oily substance.

Provenance & Evidence