Ethyl Acetate → HCID 58508929, compound

Participants

Reaction Steps

To a solution mixture of the obtained tert-butyl 2-(2-(benzyloxy)-4-(pyridin-3-yl)benzamido)-4-phenylbenzoate (0.13 g) in methanol (2 mL), dioxane (4 mL), and ethyl acetate (4 mL), 10% palladium-carbon (63 mg) was added, followed by stirring under a hydrogen atmosphere at room temperature for 2 hours. The insoluble substance was removed by filtration, and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography [Fuji Silysia Chemical Ltd., PSQ100B (spherical), eluent: 90-40% hexane/ethyl acetate] to obtain 0.077 g of tert-butyl 2-(2-hydroxy-4-(pyridin-3-yl)benzamido)-4-phenylbenzoate as a white solid.

Provenance & Evidence