Chloroform → HCID 58508678, compound

Participants

Reaction Steps

To a solution mixture of the obtained tert-butyl 2-(2-(benzyloxy)-4-(pyridin-2-yl)benzamido)-4-phenylbenzoate (0.13 g) in methanol (2 mL), dioxane (2 mL), and ethyl acetate (4 mL), 10% palladium-carbon (67 mg) was added, followed by stirring under a hydrogen atmosphere at room temperature for 2 hours and 30 minutes. Chloroform was added to the reaction mixture. The insoluble substance was removed by filtration, and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography [Fuji Silysia Chemical Ltd., PSQ100B (spherical), eluent: chloroform] to obtain 0.11 g of tert-butyl 2-(2-hydroxy-4-(pyridin-2-yl)benzamido)-4-phenylbenzoate as a white solid.

Provenance & Evidence