Trifluoroacetic acid → HCID 46853603, compound

Participants

Reaction Steps

A trifluoroacetic acid (5 mL) solution of the obtained tert-butyl 2-(2-hydroxy-4-(pyridin-2-yl)benzamido)-4-phenylbenzoate (0.11 g) was stirred at room temperature for 3 hours. The solvent was evaporated under reduced pressure, and water and ethyl acetate were added to the obtained residue. After adjusting the pH to 6.0 with a saturated aqueous solution of sodium bicarbonate, the solid substance was collected by filtration. Water (4 mL), methanol (4 mL), and dioxane (4 mL) were added to the obtained solid substance, and carbon dioxide gas was introduced thereinto at room temperature. The solvent was evaporated under reduced pressure, and water was added to the obtained residue. The solid substance was collected by filtration to obtain 0.072 g of 2-(2-hydroxy-4-(pyridin-2-yl)benzamido)-4-phenylbenzoic acid as a light yellow solid.

Provenance & Evidence