1,4-Dioxane → HCID 58508729, compound

Participants

Reaction Steps

To a solution mixture of the obtained tert-butyl 2-(2-(benzyloxy)-5-(pyrimidin-5-yl)benzamido)-4-phenylbenzoate (1.1 g) in ethyl acetate (10 mL), methanol (20 mL), and dioxane (20 mL), 10% palladium-carbon (0.57 g) was added, followed by stirring under a hydrogen atmosphere at room temperature for 2 hours and 20 minutes. The insoluble substance was removed by filtration, and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography [Fuji Silysia Chemical Ltd., PSQ100B (spherical), eluent: 70-0% hexane/ethyl acetate] to obtain 0.73 g of tert-butyl 2-(2-hydroxy-5-(pyrimidin-5-yl)benzamido)-4-phenylbenzoate as a white solid.

Provenance & Evidence