Trifluoroacetic acid → HCID 46853620, compound

Participants

Reaction Steps

A trifluoroacetic acid (4.0 mL) solution of the obtained tert-butyl 2-(2-hydroxy-5-(pyridin-3-yl)benzamido)-4-(2-methoxyphenyl)benzoate was stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure, and toluene was added to the residue. The solvent was evaporated under reduced pressure, and diisopropyl ether was added to the obtained residue. The solid substance was collected by filtration. Dioxane (2.0 mL) and a 2 mol/L aqueous solution of sodium hydroxide (0.49 mL) were added to the obtained solid substance, followed by stirring at room temperature for 45 minutes. A 10% aqueous solution of citric acid was added to the reaction mixture, and the solid substance was collected by filtration. Ethanol and water were added to the obtained solid substance, and the solid substance was collected by filtration to obtain 0.053 g of 2-(2-hydroxy-5-(pyridin-3-yl)benzamido)-4-(2-methoxyphenyl)benzoic acid as a white solid.

Provenance & Evidence