Methanol → HCID 58508841, compound

HRID 454562Notes

Reaction equation

HRID 454562 reaction equation
CO.[OH-].[Na+].C([O:8][C:9]1[CH:33]=[CH:32][C:31]([C:34]([CH3:37])([CH3:36])[CH3:35])=[CH:30][C:10]=1[C:11]([NH:13][C:14]1[CH:23]=[C:22]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:21]=[CH:20][C:15]=1[C:16]([O:18]C)=[O:17])=[O:12])(=O)C>C1(C)C=CC=CC=1>[C:34]([C:31]1[CH:32]=[CH:33][C:9]([OH:8])=[C:10]([CH:30]=1)[C:11]([NH:13][C:14]1[CH:23]=[C:22]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:21]=[CH:20][C:15]=1[C:16]([OH:18])=[O:17])=[O:12])([CH3:37])([CH3:35])[CH3:36]

Participants

5

Reactant 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 66990284HCID 66990284, compound

Product 1

HCID 58508841HCID 58508841, compoundYield 49.7%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Methanol (2 mL) and a 2 mol/L aqueous solution of sodium hydroxide (0.26 mL) were added to the obtained methyl 2-(2-acetoxy-5-tert-butylbenzamido)-4-phenylbenzoate (0.023 g), followed by stirring at room temperature for 15 hours. Toluene was added to the reaction mixture. The aqueous layer was separated and adjusted to a pH of 3.0 with 6 mol/L hydrochloric acid. The solid substance was collected by filtration to obtain 0.010 g of 2-(5-tert-butyl-2-hydroxybenzamido)-4-phenylbenzoic acid as a white solid.

Workup

  1. customThe aqueous layer was separated
  2. filtrationThe solid substance was collected by filtration

Sources & evidence

ORD record
ord-a9fdb82c90854f73ae350a2f91b6d295
Source dataset
uspto-grants-2013_07
Patent number
US08492582B2

Reaction notes

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