Citric Acid → HCID 58508845, compound

Participants

Reaction Conditions

Reaction Steps

Dioxane (5.0 mL) and a 4 mol/L aqueous solution of sodium hydroxide (0.20 mL) were added to the obtained methyl 2-(2-acetoxy-5-isopropoxybenzamido)-4-phenylbenzoate (0.072 g), followed by stirring at 50 to 60° C. for 4 hours. The reaction mixture was cooled to room temperature, and a 4 mol/L aqueous solution of sodium hydroxide (0.081 mL) was added thereto, followed by stirring at 55 to 60° C. for 2 hours. The reaction mixture was cooled to room temperature, and a 4 mol/L aqueous solution of sodium hydroxide (0.040 mL) was added thereto, followed by stirring at 60° C. for 1 hour and 30 minutes. The reaction mixture was cooled to room temperature, and a 10% aqueous solution of citric acid (9 mL) was added thereto. The solid substance was collected by filtration to obtain 0.039 g of 2-(2-hydroxy-5-isopropoxybenzamido)-4-phenylbenzoic acid as a white solid.

Provenance & Evidence