Citric Acid → HCID 58508566, compound

Participants

Reaction Steps

Dioxane (3 mL) and a 2 mol/L aqueous solution of sodium hydroxide (0.19 mL) were added to the obtained methyl 2-(2-acetoxy-5-(pyridin-3-yl)benzamido)-4-(furan-2-yl)benzoate (0.18 g), followed by stirring at room temperature for 3 hours and 10 minutes and then at 70° C. for 1 hour and 30 minutes. The reaction mixture was cooled to room temperature and adjusted to a pH of 6.0 with a 10% aqueous solution of citric acid. The solid substance was collected by filtration, and methanol (1.0 mL) and a 1 mol/L aqueous solution of sodium hydroxide (0.055 mL) were added thereto. The solid substance was collected by filtration to obtain 0.044 g of sodium 4-(furan-2-yl)-2-(2-hydroxy-5-(pyridin-3-yl)benzamido)benzoate as a white solid.

Provenance & Evidence