Trifluoroacetic acid → Methyl 2-(2-(benzyloxy)-5-(piperidin-4-yl)benzamido)-4-phenylbenzoate

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Reaction Steps

Trifluoroacetic acid (1.0 mL) was added to a chloroform (2.0 mL) solution of the obtained methyl 2-(2-(benzyloxy)-5-(1-(tert-butoxycarbonyl)piperidin-4-yl)benzamido)-4-phenylbenzoate (0.19 g), followed by stirring at room temperature for 1 hour and 30 minutes. The solvent was evaporated under reduced pressure, and water was added to the residue. After adjusting the pH to 7.4 with a saturated aqueous solution of sodium bicarbonate, chloroform was added thereto. The organic layer was separated, washed with a saturated aqueous solution of sodium chloride, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to obtain 0.15 g of methyl 2-(2-(benzyloxy)-5-(piperidin-4-yl)benzamido)-4-phenylbenzoate as a white solid.

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