反应详情

A 37% formaldehyde aqueous solution (6.3 μL), acetic acid (0.022 mL), and sodium triacetoxyborohydride (0.10 g) were sequentially added to a tetrahydrofuran (3.0 mL) solution of methyl 2-(2-(benzyloxy)-5-(piperidin-4-yl)benzamido)-4-phenylbenzoate (0.10 g), followed by stirring at room temperature for 3 hours and 30 minutes. The solvent was evaporated under reduced pressure, and a saturated aqueous solution of sodium bicarbonate and chloroform were added to the residue. The organic layer was separated and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography [eluent: 98-90% chloroform/methanol] to obtain 0.086 g of methyl 2-(2-(benzyloxy)-5-(1-methylpiperidin-4-yl)benzamido)-4-phenylbenzoate as a white solid.

1. customThe solvent was evaporated under reduced pressure
2. additiona saturated aqueous solution of sodium bicarbonate and chloroform were added to the residue
3. customThe organic layer was separated
4. dry with materialdried over anhydrous magnesium sulfate
5. customthe solvent was evaporated under reduced pressure
6. customThe obtained residue was purified by silica gel column chromatography [eluent: 98-90% chloroform/methanol]