Trifluoroacetic acid → HCID 136198185, compound

Participants

Reaction Steps

Trifluoroacetic acid (5 mL) was added to the obtained tert-butyl 2-(5-(6-aminopyridin-2-yl)-2-hydroxybenzamido)-4-phenylbenzoate (0.032 g), followed by stirring at room temperature for 12 hours. The solvent was evaporated under reduced pressure, and water and ethyl acetate were added thereto. After adjusting the pH to 6 with a saturated aqueous solution of sodium bicarbonate, the solid substance was collected by filtration. Carbon dioxide gas was introduced into a solution mixture of water (1 mL), methanol (0.5 mL), and dioxane (0.5 mL) containing the obtained solid substance, and the solid substance was collected by filtration to obtain 0.018 g of 2-(5-(6-aminopyridin-2-yl)-2-hydroxybenzamido)-4-phenylbenzoic acid as a white solid.

Provenance & Evidence