Trifluoroacetic acid → HCID 58508575, compound

Participants

Reaction Steps

Trifluoroacetic acid (5 mL) was added to the obtained tert-butyl 2-(2-hydroxy-4-(methylamino)benzamido)-4-phenylbenzoate (0.027 g), followed by stirring at room temperature for 3 hours. The solvent was evaporated under reduced pressure, and water and ethyl acetate were added to the residue, followed by adjusting the pH to 6 with a saturated aqueous solution of sodium bicarbonate. The organic layer was separated, washed with a saturated aqueous solution of sodium chloride, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. Hexane and diisopropyl ether were added to the obtained residue, and the solid substance was collected by filtration to obtain 0.014 g of 2-(2-hydroxy-4-(methylamino)benzamido)-4-phenylbenzoic acid as a light yellow solid.

Provenance & Evidence