Trifluoroacetic acid → 2-(2-Hydroxy-5-(methyl(2-(morpholin-4-yl)ethyl)amino)benzamido)-4-phenylbenzoic acid

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Reaction Steps

Trifluoroacetic acid (5.0 mL) was added to the obtained tert-butyl 2-(2-hydroxy-5-(methyl(2-(morpholin-4-yl)ethyl)amino)benzamido)-4-phenylbenzoate (0.074 g), followed by stirring at room temperature for 3 hours. The solvent was evaporated under reduced pressure, and water and chloroform were added to the residue. After adjusting the pH to 7.0 with a saturated aqueous solution of sodium bicarbonate, the organic layer was separated, and the aqueous layer was extracted with chloroform. The organic layer and the extract were combined, and the resulting mixture was dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, and diisopropyl ether was added to the obtained residue. The solid substance was collected by filtration to obtain 0.024 g of 2-(2-hydroxy-5-(methyl(2-(morpholin-4-yl)ethyl)amino)benzamido)-4-phenylbenzoic acid as a yellow solid.

Provenance & Evidence