Hydrochloric Acid → HCID 58508776, compound

Participants

Reaction Steps

Dioxane (1.0 mL) and 6 mol/L hydrochloric acid (1.0 mL) were added to the obtained tert-butyl 2-(5-(1,4-dioxa-8-azaspiro[4,5]decan-8-yl)-2-hydroxybenzamido)-4-phenylbenzoate (0.070 g), followed by heating to reflux for 25 minutes. The reaction mixture was cooled to room temperature, and water and ethyl acetate were added thereto, followed by adjusting the pH to 5.2 with a saturated aqueous solution of sodium bicarbonate. The organic layer was separated, washed with a saturated aqueous solution of sodium chloride, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography [Kanto Chemical Co., Inc., silica gel 60 (spherical), eluent: chloroform] to obtain 0.026 g of 2-(2-hydroxy-5-(4-oxopiperidin-1-yl)benzamido)-4-phenylbenzoic acid as a yellow solid.

Provenance & Evidence