Sodium Hydroxide → HCID 58508775, compound

Participants

Reaction Conditions

Reaction Steps

A 2 mol/L aqueous solution of sodium hydroxide (0.082 mL) was added to a solution mixture of the obtained methyl 2-(4-((1-acetylpiperidin-4-yl)oxy)-2-hydroxybenzamido)-4-phenylbenzoate (0.016 g) in methanol (0.5 mL) and dioxane (0.5 mL), followed by stirring at 60° C. for 1 hour and 30 minutes. The reaction mixture was cooled to room temperature, and then methanol (1 mL), dioxane (1 mL), and a 2 mol/L aqueous solution of sodium hydroxide (0.082 mL) were added to the reaction mixture, followed by stirring at 60° C. for 3 hours. The reaction mixture was cooled to room temperature, and then the solvent was evaporated under reduced pressure. Water was added to the obtained residue, followed by adjusting the pH to 3 with 6 mol/L hydrochloric acid. The solid substance was collected from the reaction mixture by filtration to obtain 0.014 g of 2-(4-((1-acetylpiperidin-4-yl)oxy)-2-hydroxybenzamido)-4-phenylbenzoic acid as a white solid.

Provenance & Evidence