Acetic Acid → HCID 66990507, compound

Participants

Reaction Steps

A 2.0 mol/L aqueous solution of sodium hydroxide (0.37 mL) was added to a solution mixture of tert-butyl 2-(5-(2-acetoxyethyl)-2-(benzyloxy)benzamido)-4-phenylbenzoate (0.38 g) in methanol (1.9 mL) and dioxane (1.9 mL), followed by stirring at room temperature for 2 hours. Acetic acid (0.012 mL) was added to the reaction mixture. The solvent was evaporated under reduced pressure, and a saturated aqueous solution of sodium bicarbonate and ethyl acetate were added to the residue. The organic layer was separated, washed with a saturated aqueous solution of sodium chloride, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to obtain 0.35 g of tert-butyl 2-(2-(benzyloxy)-5-(2-hydroxyethyl)benzamido)-4-phenylbenzoate as a white solid.

Provenance & Evidence