HCID 58508642, compound → HCID 58508590, compound

Participants

Reaction Steps

Trifluoroacetic acid (10 mL) was added to the obtained tert-butyl 2-(2-hydroxy-5-(2-(4-methylpiperazin-1-yl)ethoxy)benzamido)-4-phenylbenzoate (1.2 g), followed by stirring at room temperature for 2 hours. The solvent was evaporated under reduced pressure, and a 30% aqueous solution of methanol was added to the residue. After adjusting the pH to 6.7 with a saturated aqueous solution of sodium bicarbonate, the solid substance was collected from the reaction mixture by filtration to obtain 0.86 g of 2-(2-hydroxy-5-(2-(4-methylpiperazin-1-yl)ethoxy)benzamido)-4-phenylbenzoic acid.

Provenance & Evidence