HCID 58508818, compound → HCID 58508938, compound

Participants

Reaction Steps

Trifluoroacetic acid (10 mL) was added to the obtained tert-butyl 2-(5-(2-(4-ethylpiperazin-1-yl)ethoxy)-2-hydroxybenzamido)-4-phenylbenzoate, followed by stirring at room temperature for 3 hours. The solvent was evaporated under reduced pressure, and a 30% aqueous solution of methanol (16 mL) was added to the residue. After adjusting the pH to 6.5 with a saturated aqueous solution of sodium bicarbonate, the solid substance was collected from the reaction mixture by filtration to obtain 1.1 g of 2-(5-(2-(4-ethylpiperazin-1-yl)ethoxy)-2-hydroxybenzamido)-4-phenylbenzoic acid as a white solid.

Provenance & Evidence