Methanesulfonic Acid → 2-(5-(2-(Diethylamino)ethoxy)-2-hydroxybenzamido)-4-phenylbenzoic acid

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Reaction Steps

Dioxane (3.0 mL) and a 4 mol/L aqueous solution of sodium hydroxide (0.19 mL) were added to the obtained methyl 2-(5-(2-(diethylamino)ethoxy)-2-hydroxybenzamido)-4-phenylbenzoate (0.087 g), followed by stirring at room temperature for 2 hours and 30 minutes and then at 50 to 55° C. for 2 hours. The reaction mixture was cooled to room temperature and adjusted to a pH of 6.9 with methanesulfonic acid, and the solvent was evaporated under reduced pressure. Water was added to the obtained residue, and the solid substance was collected by filtration to obtain 0.079 g of 2-(5-(2-(diethylamino)ethoxy)-2-hydroxybenzamido)-4-phenylbenzoic acid.

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