Potassium Carbonate → HCID 66990525, compound

Participants

Reaction Steps

Potassium carbonate (0.031 g) and 3-bromo-1-propanol (0.013 mL) were added to a 2-butanone (1.3 mL) solution of methyl 2-(2-(benzyloxy)-5-(2-(piperazin-1-yl)ethoxy)benzamido)-4-phenylbenzoate (0.084 g), followed by heating to reflux for 1 hour. The reaction mixture was cooled to room temperature, and then a saturated aqueous solution of sodium bicarbonate and ethyl acetate were added thereto. The organic layer was separated, washed with a saturated aqueous solution of sodium chloride, and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography [Kanto Chemical Co., Inc., silica gel 60 (spherical), eluent: 100-91% chloroform/methanol] to obtain 0.036 g of methyl 2-(2-(benzyloxy)-5-(2-(4-(3-hydroxypropyl)piperazin-1-yl)ethoxy)benzamido)-4-phenylbenzoate as a light yellow oily substance.

Provenance & Evidence