HCID 66990525, compound → HCID 58508551, compound

Participants

Reaction Steps

To a solution mixture of the obtained methyl 2-(2-(benzyloxy)-5-(2-(4-(3-hydroxypropyl)piperazin-1-yl)ethoxy)benzamido)-4-phenylbenzoate (0.036 g) in ethyl acetate (1.5 mL) and methanol (1.5 mL), 10% palladium-carbon (0.018 g) was added, followed by stirring under a hydrogen atmosphere at room temperature for 2 hours and 30 hours. To the reaction mixture, 10% palladium-carbon (0.018 g) was added, followed by stirring under a hydrogen atmosphere at room temperature for 3 hours. The insoluble substance was removed by filtration, and then the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography [Kanto Chemical Co., Inc., silica gel 60 (spherical), eluent: 100-90% chloroform/methanol] to obtain 0.011 g of methyl 2-(2-hydroxy-5-(2-(4-(3-hydroxypropyl)piperazin-1-yl)ethoxy)benzamido)-4-phenylbenzoate as a light yellow solid.

Provenance & Evidence