Hydrochloric Acid → HCID 58508941, compound

Participants

Reaction Conditions

Reaction Steps

A 2.0 mol/L aqueous solution of sodium hydroxide (0.031 mL) was added to a solution mixture of the obtained methyl 2-(2-hydroxy-5-(2-(4-(3-hydroxypropyl)piperazin-1-yl)ethoxy)benzamido)-4-phenylbenzoate (0.011 g) in methanol (1.0 mL) and dioxane (1.0 mL), followed by stirring at 50° C. for 1 hour. A 2.0 mol/L aqueous solution of sodium hydroxide (0.031 mL) was added to the reaction mixture, followed by stirring at 50° C. for 1 hour. The reaction mixture was cooled to room temperature, and then water was added thereto. After adjusting the pH to 6.5 with 1.0 mol/L hydrochloric acid, ethyl acetate was added thereto. The organic layer was separated, and the aqueous layer was extracted with ethyl acetate. The organic layer and the extract were combined. The resulting mixture was washed with a saturated aqueous solution of sodium chloride and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. Diisopropyl ether was added to the obtained residue, and the solid substance was collected by filtration to obtain 6.5 mg of 2-(2-hydroxy-5-(2-(4-(3-hydroxypropyl)piperazin-1-yl)ethoxy)benzamido)-4-phenylbenzoic acid as a light yellow solid.

Provenance & Evidence