Triphenylphosphine → HCID 66991113, compound

Participants

Reaction Steps

Tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylate (0.26 g), triphenylphosphine (0.35 g), and diisopropyl azodicarboxylate (0.26 mL) were added to a tetrahydrofuran (5.0 mL) solution of methyl 2-(2-(benzyloxy)-5-hydroxybenzamido)-4-phenylbenzoate (0.50 g), followed by stirring at room temperature for 30 minutes. Triphenylphosphine (0.35 g) and diisopropyl azodicarboxylate (0.26 mL) were added to the reaction mixture, followed by stirring at room temperature for 30 minutes. Triphenylphosphine (0.35 g) and diisopropyl azodicarboxylate (0.26 mL) were added to the reaction mixture, followed by stirring at room temperature for 30 minutes. The solvent was evaporated under reduced pressure, and the obtained residue was purified by silica gel column chromatography [Kanto Chemical Co., Inc., silica gel 60 (spherical), eluent: 95-70% hexane/ethyl acetate] to obtain methyl 2-(2-(benzyloxy)-5-((1-(tert-butoxycarbonyl)piperidin-4-yl)methoxy)benzamido)-4-phenylbenzoate as a yellow oily substance.

Provenance & Evidence