Methanol → HCID 66990440, compound

Participants

Reaction Conditions

Reaction Steps

To an acetic acid (15 mL) solution of tert-butyl 2-(2-(benzyloxy)-5-(pyridin-3-yl)benzamido)-4-phenylbenzoate (0.88 g), 10% palladium-carbon (0.44 g) was added, followed by stirring under hydrogen pressure (5 kg/cm2) at 80° C. for 3 hours. The reaction mixture was cooled to room temperature, and methanol and acetic acid were added thereto. The insoluble substance was removed by filtration. The solvent was removed under reduced pressure, and chloroform and a saturated aqueous solution of sodium bicarbonate were added to the residue. The organic layer was separated, washed with a saturated aqueous solution of sodium chloride, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. Diisopropyl ether was added to the obtained residue, and the solid substance was collected by filtration to obtain 0.51 g of tert-butyl 2-(2-hydroxy-5-(piperidin-3-yl)benzamido)-4-phenylbenzoate as a white solid.

Provenance & Evidence