2-(Benzyloxy)-3-phenyl-3'-(1-(2-methoxyphenyl)vinyl)biphenyl → HCID 58238588, compound

Participants

Reaction Steps

A solution of 34 (1.1 g, 2.35 mmol) in methanol (15 mL) and ethyl acetate (30 mL) was treated with 20% palladium on activated carbon (50% wet, 0.05 g) and was hydrogenated at 40 psi in a Parr shaker for 3 hr. The catalyst was filtered out and washed with ethyl acetate. The filtrate was stripped and the crude product was purified by chromatography on silica (50 g) 2% ethyl acetate in hexane (3 L) to afford pure E1 (0.85 g, 95%).

Provenance & Evidence