Hydrochloric Acid → 2-(2-Hydroxy-5-(1-(2-hydroxyethyl)piperidin-4-yl)benzamido)-4-phenylbenzoic acid

Participants

Reaction Conditions

Reaction Steps

Methanol (1.0 mL) and a 2.0 mol/L aqueous solution of sodium hydroxide (0.37 mL) were added to the obtained methyl 2-(2-hydroxy-5-(1-(2-hydroxyethyl)piperidin-4-yl)benzamido)-4-phenylbenzoate (0.035 g), followed by stirring at 50° C. for 2 hours. After cooling the reaction mixture to room temperature and adjusting the pH to 6.0 with 2.0 mol/L hydrochloric acid, the solid substance was collected by filtration to obtain 0.030 g of 2-(2-hydroxy-5-(1-(2-hydroxyethyl)piperidin-4-yl)benzamido)-4-phenylbenzoic acid as a white solid.

Provenance & Evidence