Trifluoroacetic acid → HCID 58508434, compound

Participants

Reaction Steps

Trifluoroacetic acid (5 mL) was added to the obtained tert-butyl 4-(isoquinolin-4-yl)-2-(5-phenylpyridine-3-carboxamido)benzoate (0.10 g), followed by stirring at room temperature for 4 hours. The solvent was evaporated under reduced pressure, and ethyl acetate and water were added to the residue. After adjusting the pH to 6.5 with a 2 mol/L aqueous solution of sodium hydroxide, the solid substance was collected by filtration to obtain 81 mg of 4-(isoquinolin-4-yl)-2-(5-phenylpyridine-3-carboxamido)benzoic acid as a light yellow solid.

Provenance & Evidence