Trifluoroacetic acid → HCID 58508708, compound

Participants

Reaction Steps

Trifluoroacetic acid (4.0 mL) was added to the obtained tert-butyl 2-(5-phenylpyridine-3-carboxamido)-4-(pyridin-2-yl)benzoate (0.13 g), followed by stirring at room temperature for 1 hour. The solvent was evaporated under reduced pressure, and diisopropyl ether was added to the obtained residue. The solid substance was collected by filtration. Dioxane (3.0 mL) and a 2 mol/L aqueous solution of sodium hydroxide (0.19 mL) were added to the obtained solid, followed by stirring at room temperature for 1 hour. A 10% aqueous solution of citric acid and ethyl acetate were added to the reaction mixture, and the solid substance was collected by filtration to obtain 74 mg of 2-(5-phenylpyridine-3-carboxamido)-4-(pyridin-2-yl)benzoic acid as a white solid.

Provenance & Evidence