Sodium Hydroxide → HCID 58508774, compound

Participants

Reaction Steps

A 2 mol/L aqueous solution of sodium hydroxide (0.19 mL) was added to a dioxane (3.0 mL) suspension of the obtained methyl 4-(furan-2-yl)-2-(5-phenylpyridine-3-carboxamido)benzoate (76 mg) at room temperature, followed by stirring at the same temperature for 3 hours and 20 minutes. A 2 mol/L aqueous solution of sodium hydroxide (0.19 mL) was added to the reaction mixture at room temperature, followed by stirring at 50 to 55° C. for 4 hours. After cooling the reaction mixture to room temperature, the solvent was evaporated under reduced pressure. To the obtained residue, 1 mol/L hydrochloric acid (1.5 mL) was added. The solid substance was collected by filtration to obtain 69 mg of 4-(furan-2-yl)-2-(5-phenylpyridine-3-carboxamido)benzoic acid as a white solid.

Provenance & Evidence