Hydrochloric Acid → HCID 58508435, compound

Participants

Reaction Steps

A 1 mol/L aqueous solution of sodium hydroxide (0.67 mL) was added to a dioxane (3.0 mL) solution of the obtained methyl 4-(2-((ethyl)(methyl)amino)phenyl)-2-(5-phenylpyridine-3-carboxamido)benzoate (0.10 g) at room temperature, followed by stirring at the same temperature for 1 hour and then at 55° C. for 1 hour and 30 minutes. After cooling the reaction mixture to room temperature and adjusting the pH to 7.3 with 1 mol/L hydrochloric acid, the solvent was evaporated under reduced pressure. Water was added to the obtained residue, and the solid substance was collected by filtration. Ethanol (1.5 mL) and a 1 mol/L aqueous solution of sodium hydroxide (0.091 mL) were sequentially added to the obtained solid substance, followed by stirring at room temperature for 1 hour. Then, the solvent was evaporated under reduced pressure, and water was added to the obtained residue. The solid substance was collected by filtration to obtain 2.5 mg of sodium 4-(2-((ethyl)(methyl)amino)phenyl)-2-(5-phenylpyridine-3-carboxamido)benzoate as a yellow solid.

Provenance & Evidence