Sodium Hydroxide → Sodium 2-(5-phenylpyridine-3-carboxamido)-4-(thiophen-2-yl)benzoate

HRID 454757Notes

Reaction equation

HRID 454757 reaction equation
[OH-].[Na+:2].[C:3]1([C:9]2[CH:10]=[C:11]([C:15]([NH:17][C:18]3[CH:26]=[C:25]([C:27]4[S:28][CH:29]=[CH:30][CH:31]=4)[CH:24]=[CH:23][C:19]=3[C:20]([OH:22])=[O:21])=[O:16])[CH:12]=[N:13][CH:14]=2)[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>C(O)C>[C:3]1([C:9]2[CH:10]=[C:11]([C:15]([NH:17][C:18]3[CH:26]=[C:25]([C:27]4[S:28][CH:29]=[CH:30][CH:31]=4)[CH:24]=[CH:23][C:19]=3[C:20]([O-:22])=[O:21])=[O:16])[CH:12]=[N:13][CH:14]=2)[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1.[Na+:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 585084942-(5-Phenylpyridine-3-carboxamido)-4-(thiophen-2-yl)benzoic acid

Product 1

HCID 58508493Sodium 2-(5-phenylpyridine-3-carboxamido)-4-(thiophen-2-yl)benzoate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A 1 mol/L aqueous solution of sodium hydroxide (0.13 mL) was added to an ethanol (4.0 mL) suspension of the obtained 2-(5-phenylpyridine-3-carboxamido)-4-(thiophen-2-yl)benzoic acid (54 mg) at room temperature, followed by stirring at the same temperature for 2 hours and 30 minutes. The solvent was evaporated under reduced pressure, and water was added to the obtained residue. The solid substance was collected by filtration to obtain 35 mg of sodium 2-(5-phenylpyridine-3-carboxamido)-4-(thiophen-2-yl)benzoate as a white solid.

Workup

  1. customThe solvent was evaporated under reduced pressure, and water
  2. additionwas added to the obtained residue
  3. filtrationThe solid substance was collected by filtration

Sources & evidence

ORD record
ord-8cb1eede96274c1a8e9416671ec1cf35
Source dataset
uspto-grants-2013_07
Patent number
US08492582B2

Reaction notes

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