Sodium Hydroxide → HCID 58508470, compound

HRID 454773Notes

Reaction equation

HRID 454773 reaction equation
[OH-].[Na+:2].[OH:3][C:4]1[CH:5]=[C:6]([C:10]2[CH:18]=[CH:17][C:13]([C:14]([OH:16])=[O:15])=[C:12]([NH:19][C:20]([C:22]3[CH:23]=[N:24][CH:25]=[C:26]([C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)[CH:27]=3)=[O:21])[CH:11]=2)[CH:7]=[CH:8][CH:9]=1>C(O)C>[OH:3][C:4]1[CH:5]=[C:6]([C:10]2[CH:18]=[CH:17][C:13]([C:14]([O-:16])=[O:15])=[C:12]([NH:19][C:20]([C:22]3[CH:23]=[N:24][CH:25]=[C:26]([C:28]4[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=4)[CH:27]=3)=[O:21])[CH:11]=2)[CH:7]=[CH:8][CH:9]=1.[Na+:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 58508471HCID 58508471, compound

Product 1

HCID 58508470HCID 58508470, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethanol (4.0 mL) and a 1 mol/L aqueous solution of sodium hydroxide (0.17 mL) were sequentially added to the obtained 4-(3-hydroxyphenyl)-2-(5-phenylpyridine-3-carboxamido)benzoic acid (70 mg), followed by stirring at room temperature for 1 hour. The solvent was evaporated under reduced pressure, and ethanol and water were added to the obtained residue. The solid substance was collected by filtration to obtain 26 mg of sodium 4-(3-hydroxyphenyl)-2-(5-phenylpyridine-3-carboxamido)benzoate as a white solid.

Workup

  1. customThe solvent was evaporated under reduced pressure, and ethanol and water
  2. additionwere added to the obtained residue
  3. filtrationThe solid substance was collected by filtration

Sources & evidence

ORD record
ord-32d6ad06ef954c4fa475b9c67cc8f555
Source dataset
uspto-grants-2013_07
Patent number
US08492582B2

Reaction notes

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