Trifluoroacetic acid → 4-Phenyl-2-(4-phenylpyridine-2-carboxamido)benzoic acid

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Reaction Steps

Trifluoroacetic acid (5 mL) was added to the obtained tert-butyl 4-phenyl-2-(4-phenylpyridine-2-carboxamido)benzoate (64 mg), followed by stirring at room temperature for 3 hours. The solvent was evaporated under reduced pressure, and ethyl acetate and water were added to the obtained residue. After adjusting the pH to 6.5 with a saturated aqueous solution of sodium bicarbonate, the organic layer was separated, washed with water and a saturated aqueous solution of sodium chloride sequentially, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. Diisopropyl ether was added to the obtained residue, and the solid substance was collected by filtration to obtain 50 mg of 4-phenyl-2-(4-phenylpyridine-2-carboxamido)benzoic acid as a white solid.

Provenance & Evidence