Trifluoroacetic acid → HCID 58508822, compound

Participants

Reaction Steps

Trifluoroacetic acid (3.0 mL) was added to the obtained tert-butyl 4-anilino-2-(5-phenylpyridine-3-carboxamido)benzoate, followed by stirring at room temperature for 1 hour and 30 minutes. The solvent was evaporated under reduced pressure, and diisopropyl ether was added to the obtained residue. The solid substance was collected by filtration. Dioxane (3.0 mL) and a 2 mol/L aqueous solution of sodium hydroxide (0.068 mL) were sequentially added to the obtained solid substance, followed by stirring at room temperature for 1 hour and 30 minutes. A 10% aqueous solution of citric acid was added to the reaction mixture, and the solid substance was collected by filtration to obtain 73 mg of 4-anilino-2-(5-phenylpyridine-3-carboxamido)benzoic acid as a yellow solid.

Provenance & Evidence