反应详情

2,2-Bis(methylol)propionic acid (bisMPA; molecular weight 134.1, 22.1 g, 0.165 mol) was added in ethanol (150 mL) with Amberlyst-15 (6.8 g) and refluxed overnight. The resins were then filtered out and the filtrate was evaporated. Methylene chloride (200 mL) was added to the resulting viscous liquid to filtrate the unreacted reagent and byproduct. After the solution was dried over MgSO4 and evaporated, ethyl 2,2-bis(methylol)propionate (EtMPA) was obtained as a clear and colorless liquid (21.1 g, 86%).

1. temperaturerefluxed overnight
2. filtrationThe resins were then filtered out
3. customthe filtrate was evaporated
4. additionMethylene chloride (200 mL) was added to the resulting viscous liquid to filtrate the unreacted reagent and byproduct
5. dry with materialAfter the solution was dried over MgSO4
6. customevaporated